Get directions, maps, and traffic for san isabel, co. Isabel lake offers great fishing from rainbow trout, brook trout, kokanee salmon and brown trout. Lake Isabelle Outthere Colorado The lake is open to fishing year round and is regularly stocked by colorado parks and wildlife.available activities include fishing, hiking, camping and sledding in the winter. Lake isabel colorado directions . Drive to forest road 374 and turn left. Rye is located at 37°55′19″n 104°55′48″w / 37.92194°n 104.93°w / 37.92194; Lake isabel is a reservoir located in the san isabel national forest in pueblo and custer counties, in colorado, united states.the lake is in the wet mountains. Check flight prices and hotel availability for your visit. The lake is open to fishing year round and is regularly stocked by colorado parks and wildlife. The lake is in the wet mountains. From pueblo, drive 25 miles south on interstate 25 to exit 74. Lake isabel, custer county, colorado. Long lake is abou...